8.4 Pediatric Use NoPEF(djUMPU}ocl`<0yxk0R7?+9Ks,y Patients with a history of drug allergy or multiple drug allergies may be at increased risk of anaphylactic-type reactions to iron dextran. 3. Hb```f`` l,/`"`FOB/r7}UL DOSAGE AND ADMINISTRATION This total iron requirement reflects the amount of iron needed to restore hemoglobin concentration to normal or near normal levels plus an additional allowance to provide adequate replenishment of iron stores in most individuals with moderately or severely reduced levels of hemoglobin. The half-life of total iron, including both circulating and bound, is approximately 20 hours. Based on: Desired Hb = the target Hb in g/dl. Available for Android and iOS devices. 0000026747 00000 n PDF 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE - Allergan The stability of injectable medications after reconstitution is presented. Bookshelf 0000005917 00000 n ~q`C34&rAd oG 12.1 Mechanism of Action The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). (See Iron, oral under Interactions.). The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. *Qp"Q!J Dextran, a polyglucose, is either metabolized or excreted. In doses 500 mg, iron dextran plasma concentrations decrease exponentially with a half-life of about 6 hours. Iron Dextran (INFeD or DexFerrum ) INFeD and DexFerrum are iron dextran pro-ducts marketed in the United States. a Abciximab (reopro) Acetaminophen Acetazolamide (Diamox ) The molecular weights of INFeD and DexFerrum are 165,000 and 267,000 daltons, respectively. . Recommended dosage for treatment of iron deficiency anemia also may be determined from a table; consult manufacturers labeling. The physicochemical and mi-crobiological qualities of biological products are functions of the aseptic 7.1 Drug/Laboratory Test Interactions 4. Last updated on Dec 1, 2022. Careers. Advise the patient to consult a healthcare provider before taking any other iron containing products as this may cause serious side effects [see Warnings and Precautions (5.4)]. Azacitidine - Vidaza - GlobalRPH Alternatively the total dose may be calculated: Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW). We comply with the HONcode standard for trustworthy health information. 0 hO4,qv(8p]4SXs?_k^ '4["G!@` \ The test dose should be administered in the same recommended test site and by the same technique as described in the last paragraph of this section. Six different dialyzer membranes were investigated (polysulfone, cuprophane, cellulose acetate, cellulose triacetate, polymethylmethacrylate and polyacrylonitrile), including those considered high efficiency and high flux. Infed is given undiluted at a slow gradual rate not to exceed 50 mg (1 mL) per minute. 4. Serum ferritin peaks approximately 7 to 9 days after an intravenous dose of Infed and returns to baseline after about 3 weeks. 0000035990 00000 n Although anaphylactic reactions known to occur following INFeD administration are usually evident within a few minutes or sooner, it is recommended that at least an hour or longer elapse before the remainder of the initial therapeutic dose is given. 2.Intramuscular Injection - PRIOR TO RECEIVING THEIR FIRST INFeD THERAPEUTIC DOSE, ALL PATIENTS SHOULD BE GIVEN AN INTRAMUSCULAR TEST DOSE OF 0.5 mL. Nephron. 0000009538 00000 n .0.34% 16.2 Stability and Storage Use with extreme caution in patients with serious impairment of hepatic function. I. . It should not be used during the acute phase of infectious kidney disease. .65 mL/kg of body weight, b. 4. HdTr0+(R^ Similar effects were observed in mice and rats on administration of a single dose of 125 mg iron/kg. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Ling J, Gupta VD. 0000004693 00000 n To avoid injection or leakage into subcutaneous tissue, use Z-track injection technique (i.e., firmly push aside subcutaneous tissue over the site of injection before inserting the needle). 0000008494 00000 n Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever the solution and container permit. The maximum daily dose of INFeD should not exceed 2 mL. S39(,``sS*|JmdcA#C-"J1GSNqH4r~INF!F!39$*Lcc$,4 (x((C!GvFL|N@2 xY@C`&6[lLf9YODqV,&$tbz*OJ%]. The stability of Meropenemreconstituted in solution is influenced by the following factors: Storage temperature: The drug is stable for longer time in solutions stored at 4 to 5C than in solutions stored at 21 to 26C. It is not known if INFeD is safe and effective in children younger than 4 months of age. General considerations, the nitrosoureas and alkylating agents. Development and operation of a pharmacy-based intravenous cytotoxic reconstitution service. 06\ zp#2j)kS \(nd+?5R Dilution not recommended by manufacturers, but there have been reports of the total calculated dose of iron dextran being diluted in 2501000 mL of 0.9% sodium chloride injection for IV infusion [off-label]. Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached. The stability of injectable medications after reconstitution is presented. Fatal reactions have occurred following a test dose of iron dextran and also in patients in whom the test dose was tolerated. . 0000008022 00000 n Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Store at 20C to 25C (68F to 77F); excursions permitted to 15C to 30C (59F to 86F). 0000005561 00000 n trailer The half-life of free iron in the plasma circulation is approximately 5 hours. 5. 1986 Jul-Aug;40(4):142-63. All rights reserved. Clipboard, Search History, and several other advanced features are temporarily unavailable. 2009;23(3):223-30. doi: 10.1080/15360280903098382. Iron Dextran Monograph for Professionals - Drugs.com 3. There have been several reports in the literature describing tumors at the injection site in humans who had previously received intramuscular injections of iron-carbohydrate complexes. 0000030324 00000 n RRd::||7?_EeYU2&*[-%yWU0J@eZZ+)_P2B A_`T . Each monograph contains stability data, administration guidelines, and methods of preparation. Normal hemoglobin (males and females) Changes in serum ferritin levels represent the changes in calculated cellular non-heme iron levels. Niemiec PW Jr, Vanderveen TW, Hohenwarter MW, Gadsden RH Sr. Bullock L, Fitzgerald JF, Glick MR, Parks RB, Schnabel JG, Hancock BG. endstream endobj 52 0 obj<> endobj 53 0 obj<> endobj 54 0 obj<>stream Distributed into breast milk, but only as trace amounts of unmetabolized iron dextran. . Advise patients with pre-existing cardiovascular disease and rheumatoid arthritis that Infed administration may exacerbate symptoms and to contact their healthcare provider if any symptoms occur [see Warnings and Precautions (5.3)].
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